The Molecular Imaging and Contrast Agent Database (MICAD) program has added 18 new contrast and in vivo molecular imaging agents for research and development in molecular imaging, which is available free online.

The new agents are:

PET Agents:

• 2-Cl-[11C]-(-)-NPA target: D3 dopamine receptors
• [18F]Fluoropropyl-Tanaproget target: Progesterone receptor (PR)
• [18F]AV-45 target: Amyloid-beta peptide
• [18F]FE@SUPPY target: Adenosine A3 receptors
• 18-[18F]Fluoro-4-thia-palmitate target: Fatty acid oxidation (FAO) enzymes
• 18-[18F]Fluoro-4-thia-oleate target: Fatty acid oxidation (FAO) enzymes
• 68Ga-HBED-CC-anti-EpCAM diabody Target: Epithelial cell adhesion molecule (EpCAM)
• [68Ga]3 target: Prostate-specific membrane antigen (PSMA)
• 89Zr-DFO-J591 target: Prostate-specific membrane antigen (PSMA)

SPECT Agents:

• ¹¹¹In-Monomeric [Tyr3]octreotide target: Somatostatin receptors (SSTRs)
• ¹¹¹In-Dimeric [Tyr3]octreotide target: Somatostatin receptors (SSTRs)
• [¹²⁵I]SIB-NuB2i and [¹²⁵I]SIB-NuB2iii target: CD20

Ultrasound Agents:

• MB-Knottin target: a_vB₃, _avB₅, and a₅B₁ integrin receptors

Optical Agents:

• PEG-S-Au/SPIO target: Non-targeted
• CR2-Fc-SPIO target: Complement C3 fragments

Multimodality Agents:

• Gd-DTPA-PLGA target: Non-targeted
• Au@GdL target: Non-targeted
• Au@DTDTPA-Gd target: Non-targeted

All 929 agents are available in the MICAD database.