Patients who experience fatigue during radiotherapy for breast or prostate cancer may be reacting to activation of the proinflammatory cytokine network, an inflammatory pathway, according to an observational study published Aug. 18 in Clinical Cancer Research.

Julie Bower, PhD, an associate professor in the department of psychology and psychiatry at the University of California, Los Angeles, and colleagues, conducted research among 28 patients with breast cancer and 20 patients with prostate cancer, all early stage. Patients completed questionnaires and provided blood samples so researchers could determine the level of proinflammatory markers.

As the researchers expected, there was a strong link between radiotherapy treatment and fatigue. In a new finding, the investigators noted that increases in serum markers of cytokine activity, specifically IL-1 receptor antagonist and C-reactive protein, were also linked with fatigue.

"This study suggests that exposure to radiation is releasing these inflammatory cytokines and that may be contributing to fatigue," Bower said.

Scientists have been studying the role of inflammation in several diseases and have recently made breakthroughs about the link between inflammation and diseases like heart disease, Alzheimer's and cancer. There is growing evidence that inflammation may also contribute to depression and other behavioral disturbances, including fatigue and sleep problems, according to the authors.

Stephen Hahn, MD, chair of the department of radiation oncology at the Abramson Cancer Center at the University of Pennsylvania in Philadelphia, said this study is an important step forward in understanding the biological basis for fatigue.

"Fatigue related to radiotherapy is very common but we do not have any good idea about why it occurs. This suggests one possible mechanism and suggests an avenue for treatment," Hahn said.