PET shows immune-response brain inflammation untied to schizophrenia

Using positron emission tomography (PET), researchers in two separate studies have concluded that, contrary to popular hypothesis, neuroinflammation generated by the brain’s immune system is not directly associated with schizophrenia.

The studies have been published in the American Journal of Psychiatry and NPJ Schizophrenia, and their key findings are nicely summarized at

One team of investigators “noted that antipsychotic treatment may factor into their findings,” the website reports, but the other team “did not find evidence of increased microglial activation in antipsychotic medication-free or antipsychotic medication-naive patients either.”

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