CKD linked to increase in left-ventricular end-systolic stiffness

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Chronic kidney disease (CKD) is associated with an increase in left-ventricular end-systolic stiffness in patients with coronary heart disease (CHD), according to a new study presented last week at the 11th Annual Scientific Meeting of the Heart Failure Society of America (HFSA) in Washington, D.C.

Sanjiv Shah, MD, assistant professor of medicine, division of cardiology at Northwestern University in Chicago, and colleagues evaluated 871 patients with CHD using echocardiography and sphygmomanometry in an outpatient setting.

The study was designed to determine whether decreased 24-hour urine creatinine clearance in patients with CHD would be linked to increased left-ventricular end-systolic stiffness, which is measured noninvasively by single-beat method.

The patient population was divided into two groups, based on the creatinine clearance value, and a total of 206 (24 percent) of the patients had CKD.

"Patients with reduced creatinine clearance also have lower ejection fractions," said Shah, suggesting that elastance "is indeed a measure of left-ventricular systolic stiffness, and not a measure of contractility."

Shah said the findings implied that, "if we can come up with therapies that decrease their ventricular stiffness, these [therapies] may be able to improve the rates and symptoms of heart failure in patients with chronic kidney disease."

Shah received some sponsorship from the HFSA for this study, while the overall study was sponsored by the National Heart Lung and Blood Institute and the National Institutes of Health.