Men with type 2 diabetes and men with previous heart attack or stroke had a three- to four-fold risk of cardiovascular (CV) death compared to men without either disease in the years following the first acute event, according to a study in the Jan. 6 issue of the Canadian Medical Association Journal.
Gilles R. Dagenais, MD, and colleagues from Laval University and the University of Montreal studied a random sample of 4,376 men from Quebec, Canada, aged 35 to 64 years, who did not have cardiovascular disease in 1974 and who were followed until 1998. Three groups of incident cases were identified: diabetes without CV disease, first CV event (MI, unstable angina or stroke) without diabetes and both CV disease and diabetes. The cases were age-matched to a control group without diabetes or CV disease.
During the 24-year follow-up period, the researchers found that new diabetes without CV disease was documented in 137 men. A first CV event without diabetes was documented in 527 men. Relative to the 627 controls, men with 1 of the 2 diseases of interest had higher CV mortality than those with diabetes.
However, within the first five years after diagnosis, men with cardiovascular disease had higher cardiovascular mortality than men with diabetes, the authors wrote.
Dagenais and colleagues found that men with isolated type 2 diabetes and men with isolated CV disease had similar CV mortality rates several years after initial diagnosis of either condition.
The authors stressed that their findings reinforced the need to prevent and optimally manage diabetes and cardiovascular disease.