Using high-resolution MRI with a special coil to measure water diffusion within tissue, researchers may be able to identify cervical cancer in its early stages, according to a new study published in the November issue of Radiology.
The new technique offers better imaging of smaller tumors and may also improve surgical options when fertility-sparing procedures are being considered. The entire procedure takes approximately 15 minutes, the authors said.
"Small lesions are often difficult to image, but imaging their full extent is important in surgical planning," said study author Nandita deSouza, FRCR, professor and co-director of the Cancer Research U.K. Clinical Magnetic Resonance Research Group at the Institute of Cancer Research in London. "By adding this technique to image the diffusion, or movement, of water within tissue, we can improve the accuracy of detecting small tumors."
The American Cancer Society has estimated that 11,070 women in the United States will be diagnosed with invasive cervical cancer in 2008. Largely attributable to increased use of the Pap test, cervical cancer death rates declined 74 percent between 1955 and 1992 and continue to decline by nearly 4 percent annually.
In the 22-month study period, 59 women, ages 24 to 83, were accepted for inclusion into the study and placed into two groups. The first group consisted of 20 women awaiting biopsies due to abnormal cervical tissue development at screening and 18 women who had invasive cervical cancer confirmed by biopsy. The second group consisted of 21 women in whom it was necessary to evaluate the presence of the invasive disease.
The patients underwent high-resolution MRI with the addition of a ring coil inserted into the vagina and positioned around the cervix. The coil was designed specifically to image the cervix and enabled measurement of diffusion of water within the tissue cells. The researchers found that the diffusion of water was reduced in cancerous tissue compared to normal tissue.
"Measurement of water diffusion enabled us to differentiate cervical cancers from the normal glandular lining of the cervix," deSouza said. "Use of these measurements in conjunction with conventional MRI makes detection of early stage cervical cancer easier. I am hopeful that this technique will be used routinely in the future in patients with suspected small tumors."