Abbott, GSK to develop molecular lung cancer test

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Abbott has entered into an agreement with GlaxoSmithKline (GSK) to develop an automated molecular diagnostic test, based on polymerase chain reaction (PCR) technology, intended to screen non-small cell lung cancer tumors for expression of the MAGE-A3 antigen.

The London-based GSK said that MAGE-A3 Antigen Specific Cancer Immunotherapy (ASCI) candidate is currently being evaluated as an adjuvant treatment in resected non-small cell lung cancer in the phase III clinical study MAGRIT.

Under terms of the agreement, the Abbott Park, Ill.-based Abbott, in conjunction with GSK, will develop and commercialize a PCR test designed to detect MAGE A3 for use on the Abbott m2000 automated instrument system.

Currently, there are no FDA-approved nucleic acid-based tests for use in identifying patients who may derive treatment benefits from targeted non-small cell lung cancer therapies, according to the companies.