Carestream Molecular Imaging unveiled its new Kodak In-Vivo Multispectral system for advanced research applications along with new large Stokes shift dyes at the 2007 Radiological Society of North America (RSNA) annual conference last month in Chicago.
The new multispectral system incorporates workflow automation and advanced multispectral fluorescence, luminescence, digital x-ray and radioisotopic imaging capabilities for in vivo imaging of small animals for drug development and life science research.
It delivers highly improved sensitivity that allows researchers to precisely locate, identify and monitor changes in molecular activity of specific cells or organs within small animals, long before morphological changes can be detected. As a result, users can gain a better understanding of very early disease states which can lead to expedited development of effective therapeutics, according to Carestream.
The organization also displayed its new large Stokes shift dyes for fluorescent in vivo imaging. These dyes maximize the fluorescent signal while minimizing auto-fluorescence issues during in vivo imaging.
The new dyes, which are characterized by near infrared emission and a large Stokes shift, equip researchers to achieve a higher sensitivity of fluorescent detection deeper into tissue. Having a significantly larger Stokes shift—greater than 80 nanometers in the case of Kodak X-Sight Dyes—helps researchers eliminate much of the background that typically obstructs the fluorescent signal while allowing researchers to excite and emit the dyes at their maxima, thus resulting in far greater signal to noise. Most commercially available dyes typically have a Stokes shift between 20-30 nanometers, according to the company.
Although the Kodak X-Sight imaging agents have been optimized for Kodak Image Station and In-Vivo systems, they are also compatible with other commercially available digital imaging systems, Carestream said.
The firm also demonstrated the 3D processing capabilities of its Kodak Carestream PACS; the system offers a virtual desktop environment that allows any application to be delivered to any desktop inside or outside organization.
The latest Carestream PACS platform delivers native real-time 2D and 3D capabilities including maximum intensity projection, minimum intensity projection, multi-planar reconstruction, volume rendering, tissue definition and vessel tracking functionality. The product’s dynamic streaming capabilities reduces the need for large bandwidth network connections, even for viewing of 3D, cardiac CT and other extremely large image files, Carestream said.