Kodak showcases in-vivo multispectral imaging

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Eastman Kodak Company’s Molecular Imaging Systems announced the release of the KODAK In-Vivo Multispectral system for advanced research applications at RSNA 2006 last week in Chicago.

The technology is especially important because it “can look at a disease at its origins and thus the disease can be treated at its origins,” said Shahram Hejazi, PhD, world wide manager, molecular imaging systems, Kodak Health Group.
   
To do this, the system is capable of identifying molecular abnormalities that are the origin of disease at a very early stage, which can lead to expedited development of effective therapeutics. In vivo molecular imaging allows non-invasive measurement of biological processes within a living organism. The new system incorporates workflow automation and advanced multispectral fluorescence, luminescence, digital x-ray and radioisotopic imaging capabilities for in vivo imaging of small animals for drug development and life science research.

The In-Vivo Multispectral system’s computer controlled multispectral tuning of excitation light provides greatly enhanced sensitivity allowing for the identification and separation of multiple fluorochromes and the removal of autofluorescence background. The In-Vivo Multispectral system automatically generates and analyzes multispectral fluorochrome images with spatially co-registered x-ray and white light images for improved localization of biological markers in vivo. A wide range of excitation wavelengths, from optical through near-infrared, enable researchers to optimize imaging of a wide range of fluorochromes and biomarkers, the company said.
   
“By combining multispectral fluorescence with digital x-ray, the system’s highly improved sensitivity allows researchers to precisely locate, identify and monitor changes in molecular activity of specific cells or organs within small animals, long before morphological changes can be detected,” said Hejazi. Within the next couple of years the non-invasive system will become available for applications in human patients, he added.
   
According the Kodak, the In-Vivo Multispectral systems’ 4 million pixel, low noise cooled CCD camera is also ideal for luminescence and radioisotopic imaging. Its fully automated 10x optical zoom with auto focus and automated excitation, emission and x-ray filters easily generate highly reproducible images. True 16-bit imaging provides highly accurate grayscale resolution and broad linear dynamic range for quantitative imaging. Comprehensive KODAK Molecular Imaging Software allows full control over the system and provides accurate quantitative analysis, comparative intensity, geometry and positional analysis data.

The system will be available in 2006 in limited supply with worldwide availability expected for spring of 2007.