MICAD adds 23 new agents

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The Molecular Imaging and Contrast Agent Database (MICAD) program, which is designed to foster research and development in molecular imaging by providing free online scientific information regarding in vivo molecular imaging and contrast agents, has added 23 agents to its roster.

The new agents are:

PET agents:

  • [11C]A-844606 Target: Neuronal a7 nicotinic acetylcholine receptor (nAChR)
  • [11C]A-582941 Target: nAChR
  • [11C]A-836339 Target: Cannabinoid CB2 receptors
  • [18F]FP-OSP-1 Target: Heparan sulfate proteoglycans (HSPG)
  • [18F]6b Target: Gastrin-releasing peptide receptor (GRPR)
  • [18F]7b Target: GRPR
  • [18F]NS10743 Target: nAChR
  • anti-2-[18F]FACBC Target: L-type amino acid transporter
  • syn-3-[18F]FACBC Target: L-type amino acid transporter
  • anti-2-[18F]FACPC Target: L-type and A-type amino acid transporters
  • 64Cu-NO2A-(9-Anc)-BBN(7–14)NH2 Target: GRPR
  • 64Cu-NO2A-(AMBA)-BBN(7–14)NH2 Target: GRPR
  • 64Cu-NO2A-(6-Ahx)-BBN(7–14)NH2 Target: Gastrin-GRPR
  • [68Ga]6 Target: Prostate-specific membrane antigen (PSMA)
  • 68Ga-AM3 Target: Somatostatin receptors (SSTRs)
  • 89Zr-Df-R1507 Target: Insulin-like growth factor 1 receptor (IGF-1R)

SPECT agents:

  • [99mTc(CO)3]+-(HE)3-ZHER2:342 Target: Epidermal growth factor receptor (HER2)
  • [99mTc(CO)3]+-ZHER2:342-H6 Target: HER2
  • [99mTc(CO)3]+-H6-ZHER2:342 Target: HER2
  • 111In-DTPA-R1507 Target: IGF-1R
  • 177Lu-AM3 Target: SSTRs

MRI agents:

  • BM3h-8C8 Target: Dopamine

Multimodality agents:

  • 64Cu-DOTA/Cy5.5-2.5D Target: avB3, ? vB5, and ?5B1 integrin receptors

The comprehensive list—with 952 agents and approximately 4,000 imaging probes—is now available at the  MICAD database.