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Molecular Imaging

 

Researchers from the Chinese University of Hong Kong and Ann & Robert H. Lurie Children's Hospital of Chicago have combined international expertise and two types of technology to predict how well a deaf child can learn language after receiving cochlear implant surgery. 

A team of researchers has proven a new radiotracer, 2-18F-fluorodeoxysorbitol (18F-FDS), more adept at tracking bacterial infection in lungs than current imaging methods, while also distinguishing bacterial infection from inflammation.

Head trauma and sports—most notably football but also hockey, soccer and boxing—have been the focus of plenty of media coverage. Recent studies have shown an overwhelming majority of deceased football player’s brains contained evidence of chronic traumatic encephalopathy, or CTE.

PET is already considered the most sensitive non-surgical techniques for studying physiology, metabolism and molecular pathways, but experts believe recent developments may drastically increase its capabilities.

A team of Italian researchers used resting-state fMRI to examine functional connectivity abnormalities in the brain in patients with multiple sclerosis (MS). They wanted to see how abnormalities in cerebellar dentate nuclei (DNs) affect an individual’s balance, posture and muscle tone.

 

Recent Headlines

PET study shows oxytocin failing to aid serotonin in the autistic brain

The “cuddle hormone” and neurotransmitter oxytocin, which has been shown to improve social skills in individuals with autism spectrum disorders (ASD), does not boost beneficial serotonin activity in these patients as it clearly does in their non-autistic peers, according to a PET-based study conducted at the Institute of Cognitive Sciences in Lyon, France.

PET/MRI combination better than either alone at diagnosing high-risk prostate cancer

Researchers in Norway have shown the superiority of combined fluciclovine F-18 PET with multiparametric MRI over either modality alone for detecting and characterizing high-risk prostate cancers, according to a study published Oct. 6 in the Journal of Nuclear Medicine. 

Amyloid PET shows good additive value when standard PET isn’t conclusive on dementia

Patients with suspected dementia that remains unclarified after PET imaging with the standard radiotracer fluordeoxyglucose (FDG) should be sent for amyloid-busting PET with florbetaben (FBB), as the latter is highly useful in establishing a final diagnosis in such situations.

Changes in brain connectivity correlates with Parkinson’s symptoms

By using functional magnetic resonance imaging (fMRI) to study the organization of the brain’s connectome, researchers have shown certain alterations in the brain’s connectivity correlate with symptoms of Parkinson’s Disease (PD), such as motor disturbances.

Military scientists use PET/CT to shed longitudinal light on Zika

Scientists with the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) have used PET/CT with the radiotracer 18F-DPA-714 to find and longitudinally track brain inflammation in mice infected with the Zika virus.

PET/CT a dependable differentiator of types, origins of space-occupying brain lesions

PET/CT with fluorine-18-fluorodeoxyglucose (18F-FDG), the most commonly used radiotracer for PET neuroimaging and cancer patient management, is effective for differentiating between tumors, metastases and lymphomas in the brain and central nervous system, according to a study conducted in India and published online Sept. 15 in Nuclear Medicine Communications.

Combo of MRI, PET-CT often needed for accurate assessment of gliomas

PET-CT with any of various radiotracers is better than conventional MRI at showing the boundaries and necrotic tissue of brain tumors and other gliomas. However, MRI is better than any flavor of PET-CT at showing the tumors’ basic anatomical structure, making the MR scans essential to initial presurgical planning.

PET/CT, tumor markers combo shows potential to improve lung cancer diagnoses

When evaluating histological types of lung cancer, a combination of SUVmax and serum tumor markers can significantly improve diagnostic accuracy, according to a new study.

MRI illuminates changes in brain microstructure after concussion

Considering the growing concern about concussions in youth sports, recent research examined how advanced MRI can be used to better understand how brain injuries can result in neurobiological changes that impact clinical recovery.

Tau defects on PET emerge as prime predictors of early-onset Alzheimer’s

Younger Alzheimer’s patients have disproportionately more tau pathology on PET-CT imaging than older patients who are similarly symptomatic, according to a small multicenter European study. The authors suggest defective tau proteins alone can predict disease onset and progression, while later-developing Alzheimer’s likely owes to a confluence of contributing factors.

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