Breast-specific gamma imaging delivers higher specificity than MRI for cancer detection

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Breast-specific gamma imaging (BSGI) has equal sensitivity and greater specificity than MRI for the detection of breast cancer for patients with equivocal mammographic findings, according to the September/October issue of The Breast Journal.

Rachel Brem, MD, and colleagues at The George Washington University Medical Center compared the use of BSGI and MRI with an indeterminate mammogram for 23 women.

All findings were correlated with the pathologic diagnosis: 33 indeterminate lesions were evaluated in the study, and there were a total of nine pathologically confirmed cancers in eight patients.

There was no statistically significant difference in sensitivity of cancer detection between BSGI and MRI. The breast MRI resulted in 18 false positive cases, while BSGI demonstrated seven false positives. BSGI demonstrated a greater specificity than MRI, 71 percent and 25 percent, respectively.

The MRI was performed on a GE Healthcare 1.5T scanner, and BSGI was performed on a Dilon breast-specific gamma camera.