fMRI shows benefits of drug-free sleep therapy for chronic insomniacs
The cognitive processes related to verbal fluency are compromised in people with insomnia despite the absence of a behavioral deficit; however, these brain function alterations can be reversed through non-pharmacological treatment with sleep therapy, according to a neuroimaging study in the Sept. 1 issue of Sleep.

The study included 21 chronic insomnia patients with an average age of 61 years and 12 healthy controls with an average age of 60 years who were matched for age, sex and education. Insomnia was defined as "chronic" if it had lasted for at least 2.5 years. Participants underwent functional MRI (fMRI) during the performance of verbabal fluency tasks between 5 p.m. and 8:30 p.m.

Insomnia patients then were randomly assigned to a six-week sleep therapy group or a wait-list group. Therapy involved a combination of sleep restriction, multifaceted cognitive-behavior therapy, morning and late afternoon bright-light exposure and body temperature manipulations. After six weeks, fMRI scanning was repeated on both treatment groups during the same verbal fluency tasks.

Results of fMRI during verbal fluency tasks revealed that people with insomnia have less activation than controls in the left medial prefrontal cortex and the left interior frontal gyrus, two fluency-specific brain regions. However, participants with insomnia generated more words than controls on both the category fluency task (46.4 words compared with 38.7 words) and the letter fluency task (40.1 words compared with 32.7 words).

Post-treatment neuroimaging showed that cognitive abnormalities recovered for insomnia patients who received sleep therapy, but not for those assigned to a wait-list group. Participants in the sleep therapy group also generated more words on the verbal fluency tasks after treatment than members of the wait-list group, although the results did not achieve statistical significance.

According to the authors, the results should encourage the use of sleep therapy in clinical practice as a low-cost, non-pharmacological intervention for insomnia.

"It was surprising to see that the patients performed at a higher level than the control group, but showed reduced brain activation in their fMRI results," said principal investigator Ysbrand Der Werf, PhD, of the Netherlands Institute for Neuroscience in Amsterdam. "The success during the task may reflect a conscious effort to counteract the effect of poor sleep."