Feature: Multi-channel cardiac MR seeks to compete with CCTA

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MR angiography of upper extremity vascular disease.
Image source: Radiographics

In MRI, the higher the magnetic field (1.5T or 3T) the better the signal-to-noise ratio  (SNR), which translates into better image quality. While MRI provides unparalleled soft tissue contrast, the drawback is its temporal resolution. Whereas CT scanning of the coronary arteries takes mere seconds, MR imaging can take up to 20 minutes or even longer. The latest innovation to increase the speed of MRI is to employ multi-channel radiofrequency (RF) coils with parallel acquisition techniques.

Initially, researchers developed detector coil arrays, which enabled imaging of extended regions with increased SNR. The next technology developed was so-called parallel imaging techniques, enabled by multi-channel RF coil arrays coupled with parallel imaging reconstruction techniques, the earliest of which were known as "SMASH" and "SENSE."

"We want try to accelerate the scan to capture an even motion of the heart within a shorter period of time. We are not there yet compared with CT, but because of parallel imaging techniques being available now, cardiac MR imaging is becoming more competent," said Hiroyuki Fujita, founder and CEO of the Cleveland-based Quality Electrodynamics (QED), a company that specializes in RF coil technology, in an interview.

To support parallel imaging in cardiac applications, one also needs a high-channel count RF coil. Initially, eight-channel coils were routine, then 16, then 32. In the last few years, researchers have experimented with 128-channel RF coils. Having more receiver coils potentially allows more information to be acquired simultaneously, thereby shortening the scan time considerably.

Hardy and colleagues from GE Global Research experimented with a 128-channel body MRI with a flexible high-density receiver-coil array (J Magn Reson Imaging 2008;28:1219-1225). The array comprised two "clamshells" containing 64 coils each, with the posterior array built to maximize SNR and the anterior array design incorporating considerations of weight and flexibility as well. Researchers found that the larger number of receiver channels—compared with 32 channels—enabled significantly higher acceleration factors for parallel imaging and improved SNR, which theoretically would lead to improved sensitivity.

Schmitt and colleagues from Massachusetts General Hospital in Boston tested a 128-channel receive-only cardiac coil for highly accelerated cardiac MRI at 3T (Magn Reson Med 2008;59(6):1431-9). The in vivo measurements with the 128-channel coil resulted in SNR gains compared to a 24-channel coil (up to 2.2-fold in the apex, closest to the coronary arteries). The 128- and 32-channel coils showed similar SNR in the heart. The ability of the 128-channel coil to facilitate highly accelerated cardiac imaging, however, was demonstrated in four volunteers using acceleration factors up to seven-fold—within a single breath-hold.

While the increase in speed may be minimal between 32- and 128-channel coils, the 128-channel model allows acceleration over larger volumes and multiple different body areas, according to Daniel K. Sodickson, MD, PhD, vice chair for research in the department of radiology at New York University Langone Medical Center in New York City. "Without changing out of the coil, you can get ultrafast acquisition and comprehensive imaging of the heart and then ultrafast comprehensive imaging of the peripheral arterial system," Sodickson said in an interview.

The next step is to maximize coil fittings to the particular anatomy. "Well designed coil arrays are critical for parallel acquisition," said Stephen Riederer, PhD, director of the MR lab at the Mayo Clinic in Rochester, Minn., in an interview. "They have the potential to allow better superior and inferior coverage."

Riederer and colleagues found that the conventional coil arrays used in the lower limbs had uniform elements that, upon closer scrutiny, were found to be too wide for optimal anterior-posterior image acquisition. They designed a coil array with longer, narrower elements in the anterior-posterior positions. "We increased our spatial resolution dramatically," he said. The team is developing other element modules for all regions of the anatomy that better conform to a patient's diameters.

Speed & simplicity

With MRI, it's not just about speed; it's also about simplicity, Sodickson says. Today, the technologist needs to plan each scan plane separately,