When to Use CAD in Breast Imaging

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Finn Lindhardt, MD, senior consultant at the Breast Center in Viborg, Denmark, discusses a mammography study with a colleague. Image courtesy of Siemens Healthcare.

Over more than a decade, computer-assisted detection (CAD) technology has proven itself as a value-added tool to aid in mammography interpretation. But as breast MRI gains in popularity for use as a second study when suspicious lesions are found, breast MRI CAD is proving to be an integral part of clinical routine for interpreting breast MR exams.

With increasing awareness of prevention and treatment options available to treat early-stage breast cancer, screening and detection aids are at the top of radiologists’ “must have” lists. However, challenges remain to the overall market expansion of CAD, as many in the clinical community remain unconvinced as to the true clinical value of radiology’s “second set of eyes” in detecting and diagnosing several types of carcinomas outside of mammography.

Mammography’s mainstay

While CAD technology for mammography continues to evolve and improve, it isn’t without a few stumbling blocks along the way. In 2007, mammography CAD took a hit with the publication of an article in the New England Journal of Medicine which claimed CAD lowered diagnostic accuracy due to the number of false positives it produces. As a result, some third-party payors contemplated reducing or cutting reimbursement. But CAD held fast, supported by a large body of scientific evidence that proves its value. Today, mammography CAD continues to detect up to 20 percent more cancers and helps detects nearly 75 percent of actionable missed cancers.

“CAD is an add-on for diagnostic work or in a screening situation, to help you find something that you might miss,” says Finn Lindhardt, MD, senior consultant, Breast Center in Viborg, Denmark, a user of syngo MammoCAD from Siemens Healthcare. “You can use it for dense lesions in the breast, so that the system can mark regions of interest, showing findings [that] are suspicious.”

CAD usage in mammography acts as a marker, urging the attention of a radiologist, either experienced or inexperienced, to lesions that might otherwise get overlooked or calcifications which could be the first sign of early breast cancer. However, Lindhardt says that CAD is just another add-on tool in the radiologist’s armamentarium to help in diagnosing and screening.

“If you are an experienced mammogram reader, the use of the CAD system is not much help. But for inexperienced readers, it is more beneficial since it will find more lesions,” he says, adding that what the technology still lacks is the ability to characterize lesions or calcifications. “In Europe, we don’t get reimbursed for using CAD, but if you decide to use it, you should use it on every case to be secure that you are choosing the right lesions for scrutinizing.”

Wynn W. Adams, medical director of Kettering Breast Evaluation Centers in Ohio, agrees that mammography CAD is an add-on tool, highlighting areas of suspicion for lesions 1 cm or less in size as well as calcifications. “We are finding more things to look at and question as we become more digital and iCAD’s SecondLook Digital CAD technology is helpful in analyzing areas of suspicion.”

For Adams, CAD usage is not a necessary component of mammography workflow. “You don’t have to use it, but it is occasionally helpful,” she says. “It makes you feel a little more secure, but often it isn’t really going to add very much more that a radiologist isn’t capable of seeing for himself or herself.”

Breast MRI CAD in the clinical routine

While CAD for mammography is more like a “spell-checker” for radiologists to flag potential findings that might get overlooked, CAD for breast MRI is slightly different, proving useful, not as an add-on tool, or “spell-checker,” but as an integral component in the clinical routine.

“It is not a second reader, or early detection tool—it serves more as a computer-aided evaluation and visualization tool,” says David R. Gruen, director of the Connecticut Breast Center at Norwalk Radiology in Connecticut, and assistant chief of medical staff at Norwalk Hospital, who uses CADstream breast MRI CAD from Confirma.

What matters in breast MRI interpretation are both the morphology of a lesion, its shape, and the kinetics of the lesion, how it accumulates the intravenous gadolinium and subsequently washes out. “The reason this is important is that malignancies tend to take up intravenous