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Molecular Imaging

 

In a recent editorial published in the November issue of The New England Journal of Medicine (NEJM), Werner Hacke, MD, PhD, DSc, discussed a new era of imaging selections for patients who are looking to benefit from a thrombectomy performed long after the onset of a stroke.

According to a new study published by the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine (AJRCCM), obstructive sleep apnea (OSA) may increase elderly individuals' risk of developing Alzheimer's disease.  

Using PET with the radiotracer 18F-florbetapir, researchers in Sweden have found that the topology of amyloid clusters can help tip off clinicians to the presence and progression of Alzheimer’s disease in patients who don’t yet present symptoms.

Radiology and orthopedics researchers at Stanford have shown the prowess of nuclear imaging for identifying the specific source(s) of pain and reduced mobility in patients with chronic sciatica, a common low-back condition notorious for evading such pinpointing.

The effects of space travel on the human anatomy are extensive to say the least, taking into account the harsh impact zero gravity and the rapid ascension into space have on the bodies of astronauts. Yet, the amount of information detailing the effects spaceflight has on the configuration of astronauts' brains is limited, claimed in a recent study published by The New England Journal of Medicine and funded by the National Aeronautics and Space Administration (NASA). 

 

Recent Headlines

PET study shows oxytocin failing to aid serotonin in the autistic brain

The “cuddle hormone” and neurotransmitter oxytocin, which has been shown to improve social skills in individuals with autism spectrum disorders (ASD), does not boost beneficial serotonin activity in these patients as it clearly does in their non-autistic peers, according to a PET-based study conducted at the Institute of Cognitive Sciences in Lyon, France.

PET/MRI combination better than either alone at diagnosing high-risk prostate cancer

Researchers in Norway have shown the superiority of combined fluciclovine F-18 PET with multiparametric MRI over either modality alone for detecting and characterizing high-risk prostate cancers, according to a study published Oct. 6 in the Journal of Nuclear Medicine. 

Amyloid PET shows good additive value when standard PET isn’t conclusive on dementia

Patients with suspected dementia that remains unclarified after PET imaging with the standard radiotracer fluordeoxyglucose (FDG) should be sent for amyloid-busting PET with florbetaben (FBB), as the latter is highly useful in establishing a final diagnosis in such situations.

Changes in brain connectivity correlates with Parkinson’s symptoms

By using functional magnetic resonance imaging (fMRI) to study the organization of the brain’s connectome, researchers have shown certain alterations in the brain’s connectivity correlate with symptoms of Parkinson’s Disease (PD), such as motor disturbances.

Military scientists use PET/CT to shed longitudinal light on Zika

Scientists with the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) have used PET/CT with the radiotracer 18F-DPA-714 to find and longitudinally track brain inflammation in mice infected with the Zika virus.

PET/CT a dependable differentiator of types, origins of space-occupying brain lesions

PET/CT with fluorine-18-fluorodeoxyglucose (18F-FDG), the most commonly used radiotracer for PET neuroimaging and cancer patient management, is effective for differentiating between tumors, metastases and lymphomas in the brain and central nervous system, according to a study conducted in India and published online Sept. 15 in Nuclear Medicine Communications.

Combo of MRI, PET-CT often needed for accurate assessment of gliomas

PET-CT with any of various radiotracers is better than conventional MRI at showing the boundaries and necrotic tissue of brain tumors and other gliomas. However, MRI is better than any flavor of PET-CT at showing the tumors’ basic anatomical structure, making the MR scans essential to initial presurgical planning.

PET/CT, tumor markers combo shows potential to improve lung cancer diagnoses

When evaluating histological types of lung cancer, a combination of SUVmax and serum tumor markers can significantly improve diagnostic accuracy, according to a new study.

MRI illuminates changes in brain microstructure after concussion

Considering the growing concern about concussions in youth sports, recent research examined how advanced MRI can be used to better understand how brain injuries can result in neurobiological changes that impact clinical recovery.

Tau defects on PET emerge as prime predictors of early-onset Alzheimer’s

Younger Alzheimer’s patients have disproportionately more tau pathology on PET-CT imaging than older patients who are similarly symptomatic, according to a small multicenter European study. The authors suggest defective tau proteins alone can predict disease onset and progression, while later-developing Alzheimer’s likely owes to a confluence of contributing factors.

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