Molecular Imaging

Molecular imaging (also called nuclear medicine or nuclear imaging) can image the function of cells inside the body at the molecular level. This includes the imaging modalities of positron emission computed tomography (PET) and single photon emission computed tomography (SPECT) imaging. How does PET and SPECT imaging work? Small amounts of radioactive material (radiopharmaceuticals) injected into a patient. These can use sugars or chemical traits to bond to specific cells. The radioactive material is taken up by cells that consume the sugars. The radiation emitted from inside the body is detected by photon detectors outside the body. Computers take the data to assemble images of the radiation emissions. Nuclear images may appear fuzzy or ghostly rather than the sharper resolution from MRI and CT.  But, it provides metabolic information at a cellular level, showing if there are defects in the function of the heart, areas of very high metabolic activity associated with cancer cells, or areas of inflammation, data not available from other modalities. These noninvasive imaging exams are used to diagnose cancer, heart disease, Alzheimer’s and Parkinson’s disease, bone disorders and other disorders. 

Lab Science

New radiotracers may gain ground in FDG territory

PET/CT with the radiotracer 18F-FDG may have met its match at cancer detection in two new “FAPI” tracers based on gallium-68. The acronym stands for fibroblast activation protein inhibitor, and in a recent trial the new tracers equaled or bettered FDG PET/CT on image quality, required no fasting and yielded images in less time than FDG PET/CT.

March 14, 2019

Experts want Ontario to change law forbidding cremation of bodies treated with radioactive therapy

In Ontario, Canada, it is illegal to cremate a patient who has received the radiation treatment brachytherapy. Radiation experts are now calling on the province to change the law, according to a report by CBC News.

March 8, 2019

FDG PET/CT effectively monitors immunotherapy for melanoma patients

Measuring the effectiveness of treatment in metastatic melanoma patients is difficult, but a study published in the March issue of the Journal of Nuclear Medicine found 18F-FDG PET/CT could accurately monitor immunotherapy with ipilimumab in these patients.

March 8, 2019

ACR statement seeks to calm fears over radioactive material in cremated bodies

The American College of Radiology (ACR) and American Association of Physicists in Medicine (AAPM) released a joint statement Monday, March 5, to quell potential fears sparked by a recent research letter investigating the presence of radioactive materials in cremated bodies.

March 5, 2019

Cell phones can disrupt gamma cameras, but should they be banned?

The electromagnetic interference (EMI) emitted by cell phones may negatively impact gamma cameras, according to results of study published in the Journal of Medical Imaging and Radiation Sciences. But does that necessitate an outright ban?

February 28, 2019

Contamination of Arizona crematory raises questions of how to manage postmortem radiopharmaceuticals

The body of a 69-year-old male patient treated with lutetium-177 dotate contaminated an Arizona crematorium after radioactive material was found on equipment there, Tech Times reported. The incident has raised questions about the postmortem management of radiopharmaceuticals.

February 27, 2019

Department of Energy seeks agreement to produce Mo-99 domestically

The Department of Energy’s National Nuclear Security Administration (NNSA) has chosen four U.S. companies to begin negotiations with in an effort to produce Molybdenum-99 (Mo-99) without the use of highly enriched uranium.

February 21, 2019

Novel PET/CT tracer safe, effective for diagnosing acute venous thromboembolism

A novel PET/CT imaging agent—18F-GP1—produced a high-quality image and yielded a high detection rate for diagnosing acute venous thromboembolism (VTE), reported researchers of a study featured in the February issue of The Journal of Nuclear Medicine.

February 21, 2019

Around the web

Automated AI-generated measurements combined with annotated CT images can improve treatment planning and help referring physicians and patients better understand their disease, explained Sarah Jane Rinehart, MD, director of cardiac imaging with Charleston Area Medical Center.

Two advanced algorithms—one for CAC scores and another for segmenting cardiac chamber volumes—outperformed radiologists when assessing low-dose chest CT scans. 

"Gen AI can help tackle repetitive tasks and provide insights into massive datasets, saving valuable time," Thomas Kurian, CEO of Google Cloud, said Tuesday. 

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